The Pueblo Revolt of 1680, also known as Popé's Rebellion or Po'pay's Rebellion, was an uprising of most of the indigenous Pueblo people against the Spanish colonizers in the province of Santa Fe de Nuevo México, larger than present-day New Mexico. Incidents of brutality and cruelty, coupled with persistent Spanish policies that stoked animosity, gave rise to the eventual Revolt of 1680. The persecution and mistreatment of Pueblo people who adhered to traditional religious practices was the most despised of these. The Spaniards were resolved to abolish "pagan" forms of worship and replace them with Christianity. The Pueblo Revolt killed 400 Spaniards and drove the remaining 2,000 settlers out of the province. The Spaniards returned to New Mexico twelve years later.

The Puebloans, or Pueblo peoples, are Native Americans in the Southwestern United States who share common agricultural, material, and religious practices. Among the currently inhabited Pueblos, Taos, San Ildefonso, Acoma, Zuni, and Hopi are some of the most commonly known. Pueblo people speak languages from four different language families, and each Pueblo is further divided culturally by kinship systems and agricultural practices, although all cultivate varieties of corn (maize).