Puerto Madero, also known within the urban planning community as the Puerto Madero Waterfront, is a barrio of Buenos Aires in the Central Business District. Occupying a significant portion of the Río de la Plata riverbank, it is the site for several high-rise buildings and luxurious hotels, featuring the latest architectural trends. It is the barrio with by far the highest property price, surpassing the second-highest twofold.

The Buenos Aires Central Business District is the main commercial centre of Buenos Aires, Argentina, though not an official city ward. While the barrios of Puerto Madero and Retiro house important business complexes and modern high-rise architecture, the area traditionally known as Microcentro is located within San Nicolás and Monserrat, roughly coinciding with the area around the historic center of the Plaza de Mayo. The Microcentro has a wide concentration of offices, service companies and banks, and a large circulation of pedestrians on working days. Another name given to this unofficial barrio is La City, which refers more precisely to an even smaller sector within the Microcentro, where almost all the banking headquarters of the country are concentrated.