Puerto Rico Highway 133 (PR-133) is a major access road in Ponce, Puerto Rico. The road is 1.2 miles long and consists of three segments called "Calle Comercio", "Avenida Cuatro Calles", and "Avenida Ednita Nazario". The road has both of its endpoints, as well as its entire length, within the Ponce city limits. It runs west to east. The road is a main access road from downtown Ponce to PR-1, providing access to Guayama and all other points in the eastern portion of the Puerto Rico, and to PR-52, which provides expressway access to San Juan.

Puerto Rico Highway 1 (PR-1) is a highway in Puerto Rico that connects the city of Ponce to San Juan. Leaving Ponce, the road heads east and follows a somewhat parallel route along the southern coast of the island heading towards Salinas. At Salinas, the road turns north to cut through the Cordillera Central in its approach to San Juan. Before reaching San Juan, it climbs to make its way to the mountain town of Cayey and then it winds down into the city of Caguas on its final approach to San Juan.