Puerto Williams is a city, port and naval base on Navarino Island in Chile, and is also the southernmost populated settlement in the world. It faces the Beagle Channel. It is the capital of the Chilean Antarctic Province, one of four provinces in the Magellan and Chilean Antarctica Region, and administers the communes of Chilean Antarctic Territory and Cabo de Hornos. It has a population of 2,874, including both naval personnel and civilians. Puerto Williams claims the title of world's southernmost city. The settlement was founded in 1953, and was first named Puerto Luisa. The town was later named after John Williams Wilson, a British man who founded Fuerte Bulnes, the first settlement in the Strait of Magellan. It has served primarily as a naval base for Chile. The Chilean Navy runs the Guardiamarina Zañartu Airport and hospital, as well as nearby meteorological stations. Since the late 20th century, the number of navy personnel has decreased in Puerto Williams and the civilian population has increased. In that period, tourism and support of scientific research have contributed to an increase in economic activity.

Punta Arenas is the capital city of Chile's southernmost region, Magallanes and Antarctica Chilena. Although officially renamed as Magallanes in 1927, the name was changed back to Punta Arenas in 1938. The city is the largest south of the 46th parallel south and the most populous southernmost city in Chile and the Americas. Due to its location, it is also the coldest coastal city with more than 100,000 inhabitants in Latin America. Punta Arenas is one of the world's most southerly ports and serves as an Antarctic gateway city.