Puli Khumrī, also spelled Pul-i-Khumri or Pol-e Khomri, is a city in northern Afghanistan. Puli Khumri is the capital and largest city of Baghlan Province, whose name comes from the other major town in the province, Baghlan. The city has an estimated population of about 221,274 as of 2015, making it about the 9th-largest city of Afghanistan, and the second-largest city in northeastern Afghanistan after Kunduz. It is a major industrial city.

Baghlan is one of the thirty-four provinces of Afghanistan. It is in the north of the country. As of 2020, the province has a population of about 1,014,634.