Punta Arenas is the capital city of Chile's southernmost region, Magallanes and Antarctica Chilena. Although officially renamed as Magallanes in 1927, the name was changed back to Punta Arenas in 1938. The city is the largest south of the 46th parallel south and the most populous southernmost city in Chile and the Americas. Due to its location, it is also the coldest coastal city with more than 100,000 inhabitants in Latin America. Punta Arenas is one of the world's most southerly ports and serves as an Antarctic gateway city.

Ushuaia is the capital of Tierra del Fuego, Antártida e Islas del Atlántico Sur Province, Argentina. With a population of 82,615 and a location below the 54th parallel south latitude, Ushuaia claims the title of world's southernmost city.