Qashqadaryo Region is one of the regions of Uzbekistan, located in the south-eastern part of the country in the basin of the river Qashqadaryo and on the western slopes of the Pamir-Alay mountains. It borders with Tajikistan, Turkmenistan, Samarqand Region, Bukhara Region and Surxondaryo Region. It covers an area of 28,570 km2. The population is estimated 3,408,345 (2022), with 57% living in rural areas. The regional capital is Qarshi.

Uzbek, formerly known as Turki, is a Karluk Turkic language spoken by Uzbeks. It is the official and national language of Uzbekistan and formally succeeded Chagatai, an earlier Karluk language also known as "Turki", as the literary language of Uzbekistan in the 1920s.