Quartermile is the marketing name given to the mixed use redevelopment of the former Royal Infirmary of Edinburgh site, in Lauriston, Edinburgh. It was master-planned by architect Foster + Partners and takes its name from the fact it is a quarter mile from Edinburgh Castle and the Royal Mile and measures a quarter mile from corner to corner. It was built by Edinburgh developer Qmile Group, a holding company. The scheme comprises a mixture of new build apartments, apartments converted from existing nineteenth-century hospital buildings, new build offices, housing, and retail/leisure uses. Completed in 2018 after more than a decade of construction, it contains 1,050 apartments, 370,000 square feet (34,000 m2) of office space, 65,000 square feet (6,000 m2) of retail and leisure space and seven-acres of open landscape.

The Royal Infirmary of Edinburgh (RIE) was established in 1729, and is the oldest voluntary hospital in Scotland. The new buildings of 1879 were claimed to be the largest voluntary hospital in the United Kingdom, and later on, the Empire. The hospital moved to a new 900 bed site in 2003 in Little France. It is the site of clinical medicine teaching as well as a teaching hospital for the University of Edinburgh Medical School. In 1960 the first successful kidney transplant performed in the UK was at this hospital. In 1964 the world's first coronary care unit was established at the hospital. It is the only site for liver, pancreas, and pancreatic islet cell transplantation in Scotland, and one of the country's two sites for kidney transplantation. In 2012, the Emergency Department had 113,000 patient attendances, the highest number in Scotland. It is managed by NHS Lothian.