The Queen's University of Ireland was established formally by royal charter on 3 September 1850, as the degree-awarding university of the Queen's Colleges of Belfast, Cork, and Galway that were established in 1845 "to afford a university education to members of all religious denominations" in Ireland.

A royal charter is a formal grant issued by a monarch under royal prerogative as letters patent. Historically, they have been used to promulgate public laws, the most famous example being the English Magna Carta of 1215, but since the 14th century have only been used in place of private acts to grant a right or power to an individual or a body corporate. They were, and are still, used to establish significant organisations such as boroughs, universities and learned societies.