Queen Anne's County is located on the Eastern Shore of the U.S. state of Maryland. As of the 2020 census, the population was 49,874. Its county seat and most populous municipality is Centreville. The census-designated place of Stevensville is the county's most populous place with population of 7,442 as of 2020. The county is named for Queen Anne of Great Britain, who reigned when the county was established in 1706 during the colonial period.

The Eastern Shore of Maryland is a part of the U.S. state of Maryland that lies mostly on the east side of the Chesapeake Bay. Nine counties are normally included in the region. The Eastern Shore is part of the larger Delmarva Peninsula that Maryland shares with Delaware and Virginia.