Queen Elizabeth's High School is a mixed grammar school in Gainsborough, Lincolnshire, England. The school, established in 1983, but with a timeline to 1589, is an amalgamation of the previous Gainsborough High School and Queen Elizabeth's Grammar School.

Gainsborough is a market town, inland port and civil parish in the West Lindsey district of Lincolnshire, England. The population was 20,842 at the 2011 census, and estimated at 23,243 in 2019. It lies on the east bank of the River Trent, 18 miles (29 km) north-west of Lincoln, 16 miles (26 km) south-west of Scunthorpe, 20 miles south-east of Doncaster and 39 miles (63 km) east of Sheffield. It is England's furthest inland port at over 55 miles (89 km) from the North Sea.