Quintus Fufius Calenus was a Roman Republican politician and general. When Fufius was plebeian tribune in 61 BC he was an ally of Publius Clodius Pulcher during the Bona Dea affair. During his praetorship in 59 BC he supported Julius Caesar who was then consul. Fufius later served under Caesar at the close of the Gallic Wars and during the civil war that followed. For his services he was made consul in 47 BC. After Caesar's death in 44 BC, he supported Mark Antony against Cicero during the ensuing conflict in the senate. As an ally of Antony governing Cisalpine Gaul, he died of illness in 40 BC on the cusp of intervening in the Perusine War.

The War of Mutina was a civil war between the Roman Senate and Mark Antony in Northern Italy. It was the first civil war after the assassination of Julius Caesar. The main issue of the war were attempts by the Senate to resist Antony's forceful assumption of the strategically important provinces of Transalpine and Cisalpine Gaul from their governors. The Senate, led by Cicero and the consuls, attempted to woo Julius Caesar's heir to fight against Antony. Octavian, however, would pursue his own agenda.