The Rössing uranium mine in Namibia is the longest-running and one of the largest open pit uranium mines in the world. It is located in the Namib Desert near the town of Arandis, 70 kilometres from the coastal town of Swakopmund. Discovered in 1928, the Rössing mine started operations in 1976. In 2005, it produced 3,711 tonnes of uranium oxide, becoming the fifth-largest uranium mine with 8 per cent of global output. Namibia is the world's fourth-largest exporter of uranium.

Uranium mining is the process of extraction of uranium ore from the ground. Over 50 thousand tons of uranium were produced in 2019. Kazakhstan, Canada, and Australia were the top three uranium producers, respectively, and together account for 68% of world production. Other countries producing more than 1,000 tons per year included Namibia, Niger, Russia, Uzbekistan, the United States, and China. Nearly all of the world's mined uranium is used to power nuclear power plants. Historically uranium was also used in applications such as uranium glass or ferrouranium but those applications have declined due to the radioactivity of uranium and are nowadays mostly supplied with a plentiful cheap supply of depleted uranium which is also used in uranium ammunition. In addition to being cheaper, depleted uranium is also less radioactive due to a lower content of short-lived 234U and 235U than natural uranium.