Rēzekne is a state city in the Rēzekne River valley in the Latgale region of eastern Latvia. It is called The Heart of Latgale. Built on seven hills, Rēzekne is situated 242 kilometres east of Riga, and 63 kilometres west of the Latvian-Russian border, at the intersection of the Moscow – Ventspils railway and Warsaw – Saint Petersburg Railways. It is the 7th largest city in Latvia.

Latgale, also known as Latgalia is one of the Historical Latvian Lands. It is the easternmost region of the country and lies north of the Daugava River. While most of Latvia is historically Lutheran, Latgale is predominantly Roman Catholic: 65.3% according to a 2011 survey. After the Counter-Reformation it was the northernmost predominantly Catholic province or region in Europe. There is a considerable Eastern Orthodox minority (23.8%), of which 13.8% are Russian Orthodox Christians and 10.0% are Old Believers. As of 2020, the region's population was 255,968.