RNA-dependent RNA polymerase
Videos
RNA-dependent RNA polymerase or RNA replicase is an enzyme that catalyzes the replication of RNA from an RNA template. Specifically, it catalyzes synthesis of the RNA strand complementary to a given R
Overview of the flavivirus RdRp structure based on West Nile Virus (WNV) NS5Pol
Structure and evolution of RdRp in RNA viruses and their superfamilies
2018 phylogenetic tree with phylum branches highlighted. Negarnaviricota (brown), Duplornaviricota (green), Kitrinoviricota (pink), Pisuviricota (blue), and Lenarviricota (yellow)
Spiegelman's Monster
Videos
Spiegelman's Monster is an RNA chain of only 218 nucleotides that is able to be reproduced by the RNA replication enzyme RNA-dependent RNA polymerase, also called RNA replicase. It is named after its
RNA-dependent RNA polymerase
…RISC, which works alongside mRNAs targeted for interference to recruit more RdRps to synthesize more secondary siRNAs and repress gene expression. Spiegelman's Monster NS5B inhibitor…
Sol Spiegelman in his Laboratory c. 1965