Rafael Cárdenas Vela is a former Mexican drug lord and high-ranking lieutenant of the Gulf Cartel. He is the nephew of Antonio and Osiel Cárdenas Guillén, two men who at one time led the criminal organization.

The Gulf Cartel is a criminal syndicate and drug trafficking organization in Mexico, and perhaps one of the oldest organized crime groups in the country. It is currently based in Matamoros, Tamaulipas, directly across the U.S. border from Brownsville, Texas.