Raffaele Sansoni Galeoti Riario was an Italian Cardinal of the Renaissance, mainly known as the constructor of the Palazzo della Cancelleria and the person who invited Michelangelo to Rome. He was a patron of the arts. He was also the first adolescent to be elevated in the College of Cardinals in the history of the Holy See.

The Palazzo della Cancelleria is a Renaissance palace in Rome, Italy, situated between the present Corso Vittorio Emanuele II and the Campo de' Fiori, in the rione of Parione. It was built 1489–1513 by Baccio Pontelli and Antonio da Sangallo the Elder as a palace for Raffaele Cardinal Riario, Camerlengo of the Holy Roman Church, and is regarded as the earliest Renaissance palace in Rome.