Ralph Straus Regula was an American politician from Ohio. A member of the Republican Party, he served in the Ohio House of Representatives, the Ohio State Senate and the United States House of Representatives. He represented Ohio's 16th congressional district for 18 terms from 1973 to 2009. In the 110th Congress (2007–2009), he was the second longest serving Republican member of the House of Representatives.

The 16th congressional district of Ohio is an obsolete United States congressional district last represented by Representative Anthony Gonzalez (R). It was last located in the northeast of the state, covering Wayne County and with arms extending north into the suburbs of Cleveland, and east into Greater Akron and Stark County. The district was eliminated upon the swearing in of the 118th United States Congress on January 3, 2023, as the reapportionment after the 2020 census reduced the number of congressional districts in Ohio to fifteen.