Ramona is a 1910 American short drama film directed by D. W. Griffith, based on Helen Hunt Jackson's 1884 novel Ramona. Through a love story, the early silent short explores racial injustice to Native Americans and stars Mary Pickford and Henry B. Walthall. A copy of the print survives in the Library of Congress film archive. The film was remade in 1928 with Dolores del Río and 1936 with Loretta Young.

Ramona (1884) is an American novel written by Helen Hunt Jackson. Set in Southern California after the Mexican–American War and annexation of the territory by the United States, it explores the life of a mixed-race Scottish–Native American orphan girl. The story was inspired by the marriage of Hugo Reid and Victoria Reid.