Randle Patrick "Mac" McMurphy is the protagonist of Ken Kesey's novel One Flew Over the Cuckoo's Nest (1962). He appears in the stage and film adaptations of the novel as well. Jack Nicholson portrayed Randle Patrick McMurphy in the 1975 film adaptation, earning him an Academy Award for Best Actor. He was nominated on the "Heroes" list of AFI's 100 Years...100 Heroes & Villains, but did not make the final list. In 2019 he was ranked by film magazine Empire as the 99th Greatest Movie Character of All Time.

One Flew Over the Cuckoo's Nest is a novel by Ken Kesey published in 1962. Set in an Oregon psychiatric hospital, the narrative serves as a study of institutional processes and the human mind, including a critique of psychiatry and a tribute to individualistic principles. It was adapted into the Broadway play One Flew Over the Cuckoo's Nest by Dale Wasserman in 1963. Bo Goldman adapted the novel into a 1975 film of the same name directed by Miloš Forman, which won five Academy Awards.