The Randolph–Macon Yellow Jackets are the athletic teams that represent Randolph–Macon College, located in Ashland, Virginia, in NCAA Division III intercollegiate sports. The Yellow Jackets compete as members of the Old Dominion Athletic Conference. Altogether, Randolph–Macon sponsors 18 sports, with 9 teams for each gender. The school's newest sport of men's volleyball, introduced for the 2019 season, is the only team that does not compete in the ODAC, instead competing in the Continental Volleyball Conference.

Randolph–Macon College is a private liberal arts college in Ashland, Virginia. Founded in 1830, the college has an enrollment of more than 1,500 students. It is the second-oldest Methodist-run college in the country, and the oldest in continuous operation. The college primarily offers bachelor's degrees.