The four Raphael Rooms form a suite of reception rooms in the Apostolic Palace, now part of the Vatican Museums, in Vatican City. They are famous for their frescoes, painted by Raphael and his workshop. Together with Michelangelo's Sistine Chapel ceiling frescoes, they are the grand fresco sequences that mark the High Renaissance in Rome.

The Apostolic Palace is the official residence of the Pope, the head of the Catholic Church, located in Vatican City. It is also known as the Papal Palace, the Palace of the Vatican and the Vatican Palace. The Vatican itself refers to the building as the Palace of Sixtus V, in honor of Pope Sixtus V, who built most of the present form of the palace.