Rayne High School is located in Rayne, Louisiana, United States. The school is a part of the Acadia Parish School Board. Its mascot is the Mighty Wolves, and it has the largest enrollment of any school in the parish.

Rayne is a city in the U.S. state of Louisiana, in Acadia Parish. With a population of 7,326 at the 2020 United States census, it is nicknamed the "Frog Capital of the World", as well as the "Louisiana City of Murals". Rayne is part of the Crowley micropolitan statistical area, and within the Lafayette metropolitan statistical area in Acadiana.