The Rebellion of Túpac Amaru II was an uprising by cacique-led Aymara, Quechua, and mestizo rebels aimed at overthrowing Spanish colonial rule in Peru. The causes of the rebellion included opposition to the Bourbon Reforms, an economic downturn in colonial Peru and a grassroots revival of Inca cultural identity led by Túpac Amaru II, an indigenous cacique and the leader of the rebellion. While Amaru II was captured and executed by the Spanish in 1781, the rebellion continued for at least another year under other rebel leaders. Amaru II 's rebellion was simultaneous with the uprising of Túpac Katari in colonial-era Upper Peru.

Quechua people or Quichua people may refer to any of the indigenous peoples of South America who speak the Quechua languages, which originated among the Indigenous people of Peru. Although most Quechua speakers are native to Peru, there are some significant populations in Ecuador, Bolivia, Chile, Colombia, and Argentina.