Receptor-mediated endocytosis, also called clathrin-mediated endocytosis, is a process by which cells absorb metabolites, hormones, proteins – and in some cases viruses – by the inward budding of the
Mechanism of clathrin-dependent endocytosis
Endocytosis is triggered when a specific receptor is activated in receptor-mediated endocytosis.
Clathrin
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Clathrin is a protein that plays a role in the formation of coated vesicles. Clathrin was first isolated by Barbara Pearse in 1976. It forms a triskelion shape composed of three clathrin heavy chains
Receptor-mediated endocytosis
…cell through this process. Although receptors and their ligands can be brought into the cell through a few mechanisms (e.g. caveolin and lipid raft), clathrin-mediated endocytosis remains the best studied. Clathrin-mediated endocytosis of many receptor types begins with the ligands binding to receptors on the…
Clathrin terminal domain
clathrin heavy chain proximal repeat (linker)