The relic of the tooth of Buddha is venerated in Sri Lanka as a sacred cetiya relic of the Buddha, who is the founder of Buddhism, the fourth largest religion worldwide.

Cetiya, "reminders" or "memorials", are objects and places used by Buddhists to remember Gautama Buddha. According to Damrong Rajanubhab, four kinds are distinguished in the Pāli Canon: "Relic [Dhatu], Memorial [Paribhoga], Teaching [Dhamma], and votive [Udesaka]." Griswold, in contrast, states that three are traditional and the fourth, the Buddha Dhamma, was added later to remind monks that the true memory of Gautama Buddha can be found in his teachings. While these can be broadly called Buddhist symbolism, the emphasis tends to be on a historical connection to the Buddha and not a metaphysical one.