The Relief of Genoa took place between 28 March 1625 and 24 April 1625, during the Thirty Years' War. It was a major naval expedition launched by Spain against the French-occupied Republic of Genoa, of which the capital Genoa was being besieged by a joint Franco-Savoyard army composed of 30,000 men and 3,000 cavalry.

The Republic of Genoa was a medieval and early modern maritime republic from the years 1099 to 1797 in Liguria on the northwestern Italian coast. During the Late Middle Ages, it was a major commercial power in both the Mediterranean Sea and the Black Sea. Between the 16th and 17th centuries, it was one of the major financial centers in Europe.