Moldova's constitution provides for freedom of religion and complete separation of church and state, though the constitution cites the "exceptional importance" of Eastern Orthodox Christianity. Discrimination on the basis of religious affiliation is illegal, and incitement to religious and ethnic hatred was made illegal in May 2022. Religion in Moldova is dominated by the Eastern Orthodox branch of Christianity. According to the 2014 Moldovan census, 90 per cent of the country reported to be of the Eastern Orthodox Christian faith. Of this number, around eighty to 90 per cent of Orthodox Moldovans belong to the Moldovan Orthodox Church which is subordinate to the Russian Orthodox Church, and has played a powerful role in deepening Russia's influence in Moldova. The remaining 10–20 per cent of Orthodox Moldovans belong to the Metropolis of Bessarabia, which is subordinate to the Romanian Orthodox Church.

The Metropolis of Chișinău and All Moldova, also referred to as the Moldovan Orthodox Church, is an autonomous metropolitanate under the Russian Orthodox Church. Its canonical territory is the Republic of Moldova.