Reneé Mary Jane Rapp is an American singer-songwriter and actress. She gained recognition for starring as Regina George in the Broadway musical Mean Girls (2019–2020). She reprised the role in the 2024 film Mean Girls and also contributed to its soundtrack. Rapp has also starred in the Max comedy series The Sex Lives of College Girls (2021–present).

Regina George is the main antagonist in the 2004 film Mean Girls and its musical counterpart. She is portrayed by Rachel McAdams in the original 2004 film, was originated by Taylor Louderman in its Broadway musical version, and Reneé Rapp as the Broadway replacement and in the 2024 film adaptation of the musical.