Grey wolves were considered extirpated from the conterminous United States in the 1940s, but some survived in the remote northeastern corner of Minnesota. After they were listed as an endangered species, they naturally expanded into many of the habitats in the Midwestern states of Minnesota, Michigan, and Wisconsin they had previously occupied. These three states are estimated to have a stable population of 4,400 wolves. The western Great Lakes region they inhabit includes the forested areas of these states, along with the Canadian provinces of Manitoba and Ontario. In 1978, wolves were protected under the federal Endangered Species Act as it was determined that they were in danger of going extinct and needed protection to aid their recovery. Management under the Act allowed the remaining wolves in Minnesota to flourish and repopulate northern Wisconsin and the Upper Peninsula of Michigan. Wolves were removed from federal protection in January 2021 with management authority remaining with state and tribal authorities. Management plans guide each state's decisions about wolf regulations for hunting, trapping, and culling along with population monitoring, and livestock damage control. In February 2022, a judge ordered federal protections for gray wolves to be restored under the Federal Endangered Species Act which returned management authority to the U.S. Fish and Wildlife Service.

The Western Great Lakes forests is a terrestrial ecoregion as defined by the World Wildlife Fund. It is within the temperate broadleaf and mixed forests biome of North America. It is found in northern areas of the United States' states of Michigan, Wisconsin and Minnesota, and in southern areas of the Canadian province of Manitoba and northwestern areas of the province of Ontario.