The Republic of Florence, known officially as the Florentine Republic, was a medieval and early modern state that was centered on the Italian city of Florence in Tuscany, Italy. The republic originated in 1115, when the Florentine people rebelled against the Margraviate of Tuscany upon the death of Matilda of Tuscany, who controlled vast territories that included Florence. The Florentines formed a commune in her successors' place. The republic was ruled by a council known as the Signoria of Florence. The signoria was chosen by the gonfaloniere, who was elected every two months by Florentine guild members.

Florence is the capital city of the Italian region of Tuscany. It is also the most populated city in Tuscany, with 360,930 inhabitants in 2023, and 984,991 in its metropolitan area.