Reuben E. Brigety II is an American diplomat and academic who has served as the United States ambassador to South Africa since August 2022. He was the vice-chancellor and president of the University of the South, in Sewanee, Tennessee, from 2020 to 2021. Previously, Brigety served as dean of the Elliott School of International Affairs at George Washington University. Prior to that, Brigety has served as United States ambassador to the African Union, as a deputy assistant secretary of state, and as permanent representative to the United Nations Economic Commission for Africa.

The Lady R incident, also known as #LadyRussiagate, refers to the docking of the sanctioned Russian cargo ship Lady R at Simon's Town Naval Base in South Africa in December 2022 and the resulting diplomatic impact. The ship was carrying military cargo. The incident is controversial for the secretive nature of the docking and an allegation by the United States ambassador to South Africa that South African military supplies were loaded onto the ship for use in Russia's invasion of Ukraine.