The Rhône wine region in Southern France is situated in the Rhône valley and produces numerous wines under various Appellation d'origine contrôlée (AOC) designations. The region's major appellation in production volume is Côtes du Rhône AOC.

The Rhône is a major river in France and Switzerland, rising in the Alps and flowing west and south through Lake Geneva and southeastern France before discharging into the Mediterranean Sea. At Arles, near its mouth, the river divides into the Great Rhône and the Little Rhône. The resulting delta forms the Camargue region.