Rheinhessen is the largest of 13 German wine regions (Weinanbaugebiete) for quality wines with 26,758 hectares under cultivation in 2018. Named for the traditional region of Rhenish Hesse, it lies on the left bank of the Rhine between Worms and Bingen in the federal state of Rhineland-Palatinate. Despite its historic name it is currently no longer part of the federal-state of Hesse, this being the case since the end of World War II. There have been several unsuccessful attempts to legally reunite the former wine growing districts of Mainz on the Hessian side during the post-war area. Rheinhessen produces mostly white wine from a variety of grapes, particularly Riesling, Müller-Thurgau and Silvaner, and is best known as the home of Liebfraumilch, although some previously underrated Rieslings are also made, increasingly in a powerful dry style.

German wine is primarily produced in the west of Germany, along the river Rhine and its tributaries, with the oldest plantations going back to the Roman era. Approximately 60 percent of German wine is produced in the state of Rhineland-Palatinate, where 6 of the 13 regions (Anbaugebiete) for quality wine are situated. Germany has about 103,000 hectares of vineyard, which is around one tenth of the vineyard surface in Spain, France or Italy. The total wine production is usually around 10 million hectoliters annually, corresponding to 1.3 billion bottles, which places Germany as the eighth-largest wine-producing country in the world. White wine accounts for almost two thirds of the total production.