The Rhine-Main Railway, is a railway line in southern Germany from Mainz via Darmstadt to Aschaffenburg. It was built by the Hessian Ludwig Railway and opened on 1 August 1858 and is one of the oldest railways in Germany. Until 1862, when the railway bridge over the Rhine river constructed and assembled by MAN-Werk Gustavsburg was finished, a train ferry operated on the river.

Mainz Hauptbahnhof is a railway station for the city of Mainz in the German state of Rhineland-Palatinate. It is used by about 60,000 travelers and visitors each day and is therefore by far the busiest station in Rhineland-Palatinate. The station was a trial area for a CCTV scheme using automated face recognition.