Rice Lake is a city in Barron County in northwest Wisconsin, United States, on the shore of the lake with the same name. The city is a commercial and tourist center for the surrounding rural areas. As of the 2020 census, the city had a total population of 9,040. The city is located mostly within the Town of Rice Lake.

U.S. Route 53, or U.S. Highway 53 (U.S. 53), is a north–south U.S. highway that runs for 404 miles (650 km) from La Crosse, Wisconsin to International Falls, Minnesota. It is the primary north–south route in northwestern Wisconsin, serving as a vital link between I-94 at Eau Claire, Wisconsin and the Twin Ports of Superior, Wisconsin, and Duluth, Minnesota. The entire route from Eau Claire to the city limits of Superior is a four lane divided highway. The highway's northern terminus is at the Fort Frances–International Falls International Bridge in International Falls, Minnesota, at the Canada–US border. Its southern terminus is in La Crosse, Wisconsin, at U.S. Highway 14.