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Rick Pitino

Richard Andrew Pitino is an American professional basketball coach, the head coach for Panathinaikos of the Greek Basket League and EuroLeague. He is the head coach of Greece's senior national team, he was the head coach of several teams in NCAA Division I and in the NBA, including Boston University, Providence College, the New York Knicks, the University of Kentucky, the Boston Celtics and the University of Louisville. Pitino led Kentucky to an NCAA championship in 1996, he is the only coach to lead three different schools to a Final Four. In 2013, he was elected to the Naismith Memorial Basketball Hall of Fame. In June 2017, the NCAA suspended Pitino for five games of the upcoming 2017–18 season for his lack of oversight in an escort sex scandal involving recruits. Louisville's national championship from 2013 was vacated as well. In September, Pitino was implicated in a federal investigation involving bribes to recruits, which resulted in Louisville firing him for cause. Pitino was born in New York City, New York, was raised in Bayville, New York.

He was the team captain of the St. Dominic High School basketball team in Long Island, he enrolled at the University of Massachusetts Amherst in 1970. At a listed height of 1.83 m tall, he was a standout point guard for the Minutemen basketball team. His 329 career assists ranked tenth all-time at UMass, as of the 2009–10 season, he led the team in assists as a senior. The 168 assists as a senior is the eighth-best single season total there. Pitino was a freshman at the same time future NBA legend Julius Erving spent his junior year at UMass, although the two never played on the same team because freshmen were ineligible to play varsity basketball at the time. Other teammates of Pitino's include Al Skinner, who went on to become a successful college coach, baseball player Mike Flanagan, who went on to pitch in the major leagues and win the AL Cy Young Award in 1979. Pitino earned his degree from the University of Massachusetts Amherst in 1974. College coaching assignments included Boston University, Providence College, the University of Kentucky, the University of Louisville.

As a collegiate head coach, Pitino has compiled a 629–234 record, for a.732 winning percentage, ranked 10th among active coaches and 29th all-time among all collegiate basketball coaches entering the 2012 season. Pitino is considered by many to be one of the first coaches to promote taking advantage of the 3-point shot, first adopted by the NCAA in 1987. By exploiting the 3-point shot, his teams at Kentucky in the early 1990s were known as Pitino's Bombinos, as a significant portion of the offensive points came from the 3-point shot. Now, Pitino's teams are known for the 3-point threat and all of his teams rank towards the top in 3-point attempts per season. Many of Pitino's players and assistant coaches have gone on to become successful collegiate coaches. In total, 21 former Pitino players and coaches have become Division I head coaches, including Florida's Billy Donovan, Texas Tech's Tubby Smith, Arizona State's Herb Sendek, Cincinnati's Mick Cronin, Minnesota's Richard Pitino, Seton Hall's Kevin Willard as well as Cal State Northridge's Reggie Theus.

Pitino started his coaching career as a graduate assistant at the University of Hawaii in 1974, became a full-time assistant in 1975. He was the first assistant hired by Jim Boeheim in 1976 as Boeheim began his tenure at Syracuse University. Pitino served as Hawaii's interim head coach late in the 1975–76 season. Coach Bruce O'Neil was fired after the Rainbow Warriors' started the season 9–12. Pitino led Hawaii for their final six games. Pitino's time at Hawaii was marred by a 1977 NCAA report on sanctions against the program. According to the report, Pitino was implicated in 8 of the 64 infractions that led the university to be placed on probation; the violations involving Pitino included providing round-trip air fare for a player between New York and Honolulu, arranging for student-athletes to receive used cars for season tickets, handing out coupons to players for free food at McDonald's. He was cited, along with the head coach, Bruce O'Neil, for providing misinformation to the NCAA and University of Hawaii officials.

In 1977, the NCAA infractions committee recommended that Pitino and O'Neil be disassociated from Hawaii athletics. In 1989, Pitino would dismiss the report, saying "I didn't make any mistakes, I don't care what anybody says." Pitino's first head coaching job came in 1978 at Boston University. In the two seasons before his arrival, the team had won a mere 17 games. Pitino led the team to its first NCAA tournament appearance in 24 years. Pitino left Boston University to become an assistant coach with the New York Knicks under Hubie Brown. Pitino returned to college coaching to become head coach at Providence College in 1985. Providence had gone a dismal 11 -- 20 in the year. Two years Pitino led the team to the Final Four; that Final Four team featured point guard Billy Donovan, who would go on to be an assistant coach under Pitino at the University of Kentucky and win back-to-back national championships as head coach at the University of Florida. Donovan is the head coach of the Oklahoma City Thunder.

After spending two years coaching in the NBA, Pitino returned to the college level again in 1989, becoming the coach at Kentucky. The Kentucky program was recovering from a major recruiting scandal brought on by former coach Eddie Sutton that left it on NCAA probation. Pitino restored Kentucky's reputation and performance, leading his second sc

Diamond–Blackfan anemia

Diamond–Blackfan anemia is a congenital erythroid aplasia that presents in infancy. DBA causes low red blood cell counts, without affecting the other blood components, which are normal; this is in contrast to Shwachman–Bodian–Diamond syndrome, in which the bone marrow defect results in neutropenia, Fanconi anemia, where all cell lines are affected resulting in pancytopenia. A variety of other congenital abnormalities may occur in DBA. Diamond–Blackfan anemia is characterized by normocytic or macrocytic anemia with decreased erythroid progenitor cells in the bone marrow; this develops during the neonatal period. About 47% of affected individuals have a variety of congenital abnormalities, including craniofacial malformations, thumb or upper limb abnormalities, cardiac defects, urogenital malformations, cleft palate. Low birth weight and generalized growth delay are sometimes observed. DBA patients have a modest risk of other malignancies. Most pedigrees suggest an autosomal dominant mode of inheritance with incomplete penetrance.

10–25% of DBA occurs with a family history of disease. About 25-50% of the causes of DBA have been tied to abnormal ribosomal protein genes; the disease is characterized by genetic heterogeneity, affecting different ribosomal gene loci: Exceptions to this paradigm have been demonstrated, such as with rare mutations of transcription factor GATA1 and advanced alternative splicing of a gene involved in iron metabolism, SLC49A1. In 1997, a patient was identified who carried a rare balanced chromosomal translocation involving chromosome 19 and the X chromosome; this suggested that the affected gene might lie in one of the two regions that were disrupted by this cytogenetic anomaly. Linkage analysis in affected families implicated this region in disease, led to the cloning of the first DBA gene. About 20–25% of DBA cases are caused by mutations in the ribosome protein S19 gene on chromosome 19 at cytogenetic position 19q13.2. Some undiagnosed relatives of DBA patients were found to carry mutations, had increased adenosine deaminase levels in their red blood cells, but had no other overt signs of disease.

A subsequent study of families with no evidence of RPS19 mutations determined that 18 of 38 families showed evidence for involvement of an unknown gene on chromosome 8 at 8p23.3-8p22. The precise genetic defect in these families has not yet been delineated. Malformations are seen more with DBA6 RPL5 and DBA7 RPL11 mutations; the genetic abnormalities underpinning the combination of DBA with Treacher Collins syndrome /mandibulofacial dysostosis phenotypes are heterogeneous, including RPS26, TSR2 which encodes a direct binding partner of RPS26, RPS28. The phenotype of DBA patients suggests a hematological stem cell defect affecting the erythroid progenitor population. Loss of ribosomal function might be predicted to affect translation and protein biosynthesis broadly and impact many tissues. However, DBA is characterized by dominant inheritance, arises from partial loss of ribosomal function, so it is possible that erythroid progenitors are more sensitive to this decreased function, while most other tissues are less affected.

A diagnosis of DBA is made through a blood count and a bone marrow biopsy. A diagnosis of DBA is made on the basis of anemia, low reticulocyte counts, diminished erythroid precursors in bone marrow. Features that support a diagnosis of DBA include the presence of congenital abnormalities, elevated fetal hemoglobin, elevated adenosine deaminase levels in red blood cells. Most patients are diagnosed in the first two years of life. However, some mildly affected individuals only receive attention after a more affected family member is identified. About 20–25% of DBA patients may be identified with a genetic test for mutations in the RPS19 gene. Corticosteroids can be used to treat anemia in DBA. In a large study of 225 patients, 82% responded to this therapy, although many side effects were noted; some patients remained responsive to steroids. Blood transfusions can be used to treat severe anemia in DBA. Periods of remission may occur, during which steroid treatments are not required. Bone marrow transplantation can cure hematological aspects of DBA.

This option may be considered when patients become transfusion-dependent because frequent transfusions can lead to iron overloading and organ damage. However, adverse events from BMTs may exceed those from iron overloading. A 2007 study showed the efficacy of isoleucine supplementation in one patient. Larger studies are being conducted. First noted by Hugh W. Josephs in 1936, the condition is however named for the pediatricians Louis K. Diamond and Kenneth Blackfan, who described congenital hypoplastic anemia in 1938. Responsiveness to corticosteroids was reported in 1951. In 1961, Diamond and colleagues presented longitudinal data on 30 patients and noted an association with skeletal abnormalities. In 1997, a region on chromosome 19 was determined to carry a gene mutated in some DBA. In 1999, mutations in the ribosomal protein S19 gene were found to be associated with disease in 42 of 172 DBA patients. In 2001, a second DBA gene was localized to a region of chromosome 8, further genetic heterogeneity was inferred.

Additional genes were subsequently identified. A girl named Audrey Nethery of Louisville, Kentucky has a large online following from her singing and dancing videos and has brought public attention to the rare disease

IAE Universidad Austral

IAE Business School is the Management and Business School of the Argentine Austral University. It is located in the suburb of Pilar in Argentina; the IAE Business School has one of the biggest alumni communities in Latin America with over 15.000 graduates distributed in more than 25 countries. In the 2010 QS Global 200 Business Schools Report IAE Business School was placed as the 6th best business school in Latin America. In the 2011 Financial Times executive education ranking, the school ranked 26th worldwide, third in Latin America. MBA, full-time, one year. IAE offers two EMBA program formats: the two-year Executive MBA and the Regional EMBA; the latter can not attend regular weekly classes. Ph. D. in Business Management. Since 1978, enrollment in IAE's executive training programs has exceeded 1,700. General Management Programs Focused Programs Customized Programs Specialty Programs IAE is the only Argentine business school with Triple accreditation: AACSB - The Association to Advance Collegiate Schools of Business AMBA - Association of MBAs EQUIS - European Quality Improvement System IAE Business School offers international executive programs jointly with the IESE Business School and Harvard Business School.

IAE's campus stands on 20 of the 237 acres in the Universidad Austral Campus. It is located a few yards from the 8 National Highway; the four buildings have a total area of 242.196 sq ft.. The Campus includes the University Hospital, inaugurated in March 2000, it houses the nine other faculties and schools of the University. Official website