The Riley Hospital for Children at Indiana University Health is a nationally ranked freestanding 456-bed, pediatric acute care children's hospital in Indianapolis, Indiana, United States. It is affiliated with the Indiana University School of Medicine. Riley Hospital for Children is a member of the Indiana University Health system, the only children's hospital in the network. The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21 throughout Indiana and features an ACS verified level I pediatric trauma center. Its regional pediatric intensive-care unit and neonatal intensive care units serve the entire Midwest region. In addition, Riley has two helipads for rapid transport of emergent pediatric care. Riley Hospital for Children is named for James Whitcomb Riley, a writer and poet who lived in Indianapolis.

James Whitcomb Riley was an American writer, poet, and best-selling author. During his lifetime he was known as the "Hoosier Poet" and "Children's Poet" for his dialect works and his children's poetry. His poems tend to be humorous or sentimental. Of the approximately 1,000 poems Riley wrote, the majority are in dialect. His famous works include "Little Orphant Annie" and "The Raggedy Man".