Rio Grande is a village in Gallia County, Ohio, United States. The population was 724 at the 2020 census. It is part of the rural Point Pleasant micropolitan area. Although the town is named after the river in the southern United States, its name is pronounced "Rye-O Grand" rather than the traditional Spanish pronunciation.

Gallia County is a county located in the U.S. state of Ohio. As of the 2020 census, the population was 29,220. Its county seat and largest village is Gallipolis.