The Rio Grande Valley is the river valley carved out by the Rio Grande as it flows through the American Southwest and northeastern Mexico, forming a part of the border region. In the US state of New Mexico, the river flows mostly north to south, and forms a valley near Cochiti Pueblo to the state line near El Paso, Texas along the floors of the large sedimentary basins of the Rio Grande Rift, and includes the narrow sections between the basins. It has been historically settled first by the Pueblo peoples, the Spanish, the Mexicans, and finally Anglo-Americans. As the largest river in the state, some of its most populous cities are located wholly or partially in the valley, including Albuquerque, New Mexico's largest city.

The Rio Grande in the United States or the Río Bravo in Mexico is one of the principal rivers in the southwestern United States and in northern Mexico. The length of the Rio Grande is 1,896 miles (3,051 km), making it the 4th longest river in the United States and in North America by main stem. It originates in south-central Colorado, in the United States, and flows to the Gulf of Mexico. The Rio Grande drainage basin (watershed) has an area of 182,200 square miles (472,000 km2); however, the endorheic basins that are adjacent to and within the greater drainage basin of the Rio Grande increase the total drainage-basin area to 336,000 square miles (870,000 km2).