Rionegro is a city and municipality in Antioquia Department, Colombia, located in the subregion of Eastern Antioquia. The official name of the city is Ciudad Santiago de Arma de Rionegro. Rio Negro means "Black River" in Spanish, as the city received its name after a river that looks black because of the shadows cast by trees. The river traverses the city and it is the most prominent geographical feature of the municipality. Rionegro is also sometimes called the Cuna de la democracia as it was one of the most important cities during the era of the Colombia's struggle for independence and the 1863 constitution was written in the city.

Medellín, officially the Special District of Science, Technology and Innovation of Medellín, is the second-largest city in Colombia after Bogotá, and the capital of the department of Antioquia. It is located in the Aburrá Valley, a central region of the Andes Mountains, in northwestern South America. The city's population was 2,508,452 at the 2018 census. The metro area of Medellín is the second-largest urban agglomeration in Colombia in terms of population and economy, with more than 4 million people.