Ripley is a city in Lauderdale County, Tennessee, United States. The population was 8,445 at the 2010 census. It is the county seat of Lauderdale County.

Lauderdale County is a county located on the western edge of the U.S. state of Tennessee, with its border the Mississippi River. As of the 2020 census, the population was 25,143. Its county seat is Ripley. Since the antebellum years, it has been developed for cotton as a major commodity crop.