Ripley County is a county in the Ozarks of Missouri. At the 2020 census, it had a population of 10,679. The largest city and county seat is Doniphan. The county was officially organized on January 5, 1833, and is named after Brigadier General Eleazer Wheelock Ripley, a soldier who served with distinction in the War of 1812.

Oregon County is a county located in the southern portion of the U.S. state of Missouri. As of the 2020 census, the population was 8,635. Its county seat is Alton. The county was officially organized on February 14, 1845, and was named for the Oregon Territory in the northwestern United States.