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River Aeron

The River Aeron is a small river in Ceredigion, that flows into Cardigan Bay at Aberaeron. It is referred to on some older maps as the River Ayron. Pughe's Dictionary of the Welsh Language states that Aeron in Welsh meant: "queen of brightness", it has its source in the range of hills called Mynydd Bach. It follows a more or less westerly and north westerly track to the sea, it has a rather broad river valley bounded by low hills and has few significant tributaries. Those that it does have include the Gwenffrwd, Nant Wysg, Nant Picadilly, Nant y Wernen and Nant Rhiw Afallan; the Afon Mydr drains an area of old woodlands and dairy farming and includes the old farm of Rhiwbren Fawr. On its way to the sea, the Aeron passes by the village of Ciliau Aeron, it passes close to the restored mansion at Llanerchaeron, now in the care of the National Trust before entering the town of Aberaeron where it enters the sea. Despite the small size of the river, it sustains a population of salmon and brown trout. Dylan Thomas lived near the banks of the river in the 1940s, at a secluded mansion called Plas Gelli, just outside Talsarn.

He called the Aeron valley "the most precious place in the world." The Dylan Thomas Trail follows the river from Talsarn to Aberaeron. Talsarn was the centre for a thriving group of poets who lived in and around the Aeron valley, such as John Jenkins, Dan Jenkins Pentrefelin and Dinah Davies. There are still poets in the valley today, such as the Ciliau Aeron poet, Stevie Krayer, who has written a sequence of poems about the river. Although the Aeron has suffered from intermittent pollution including some severe incidents in the 1970s caused by creamery waste and crude sewage escapes in the Felinfach area, the principal impacts are now diffuse agricultural waste, pesticides from agriculture and acidification from upland forestry plantations. Aeron poets

Statute of Catalonia of 1919

The Statute of Catalonia of 1919 started in a pro-autonomist environment and was approved by the Assembly of the Commonwealth of Catalonia in Barcelona, on 24 January 1919 with the support of several Catalan parties: The Partit Català Republicà took this Statute as its main concern, Alejandro Lerroux's radicals endorsed it, Francesc Cambó and his party asked for a pragmatic vision. Liberals and Conservatives went against central party policy, the Traditionalists remembered his defense of autonomy with weapons. Francesc Macià -speaking as a supporter of independence- said that this was a short Statute, but the best one that could be achieved. Largo Caballero, speaking as a Socialist, stated that Spanish workers believed that Catalan Autonomy was the first step in the regeneration of Spain. On 26 January, this Statute was ratified in an Assembly held at the Palau de la Música of Barcelona, which gathered all the municipal representatives together. 1,046 of 1,072 towns voted positively, as well as 2,076,251 of the 2,099,218 eligible citizens.

It got the approval of several civic entities and corporations such as the Centre Regionalista Andalús, the Football Club Barcelona, the Bloc Regionalista Castellà or the Club Sports Catalunya, in Mexico. This project was sent to the Spanish Government for its approval on 28 January 1919 with several Catalan deputies to defend it, but the Socio-political situation, which changed due to several strikes in the Catalan field, the collision between Government of Catalonia's interests and the Spanish government's ones and the dictatorship of Primo de Rivera stopped its progression; the structure of the Autonomy Statute of Catalonia, as the list made by Woodrow Wilson in the “Fourteen Points”, was approved by the Assembly of the Commonwealth is as follows: Preliminar declaration First title: About the land of Catalonia. It includes the article number 1. Second title: About the Catalan citizens, it includes the article number 2. Third title: About the Government of Catalonia, it includes the articles number 3, 4 and 5.

Fourth title: The own and exclusive faculties of the regional power. It includes the articles number 6 and 7. Fifth title: About the intervention of the regional power in general-law reguled stuff, it includes the articles number 8 and 9, 10 and 11. Sixth title: About the regional finance, it includes the articles number 12 and 13. Seventh title: About the regional Parliament, it includes the articles between number 16 and 29. Eighth title: About the general governor and the power of the regional executive, it includes the articles between number 30 and 34. And a final Temporary rules section

Immokalee, Florida

Immokalee ( is an unincorporated community and census-designated place in Collier County, United States. The region was occupied by the Calusa Indians and centuries occupied by the Seminole, after they moved down from the northern part of Florida; the settlement was known as Gopher Ridge by the Seminole and Miccosukee Indians. Immokalee means "your home" in the Mikasuki language; when the swamps were drained in the region, agriculture became the dominant industry. European-American hunters, Indian traders and missionaries moved in before the development of permanent villages; the first permanent settlement was founded in 1872. In 1921, the Atlantic Coast Line Railroad extended its Haines City Branch south to Immokalee; the railroad was removed in the late 1980s. The Immokalee area is agricultural, it is one of the major centers of tomato growing in the United States. In 1960, CBS News anchor Edward R. Murrow reported on the working conditions in the surrounding farms for his Harvest of Shame report for CBS Reports, which described the harsh lives of migrant workers.

Immokalee is located in northern Collier County along Florida State Road 29. LaBelle is 24 miles to the north, Interstate 75 is 20 miles to the south. According to the United States Census Bureau, the CDP has a total area of 23.3 square miles, of which 22.7 square miles is land and 0.58 square miles, or 2.42%, is water. The population was 24,154 at the 2010 census, it is part of the Naples–Marco Island Metropolitan Statistical Area. As of the census of 2000, there were 19,763 people, 4,715 households, 3,635 families residing in the CDP; the population density was 2,449.1 people per square mile. There were 4,987 housing units at an average density of 618.0/sq mi. The racial makeup of the CDP was 70.98% Hispanic, 18.03% African American, 3.19% White, 1.03% Native American, 0.20% Asian, 0.19% Pacific Islander, 35.66% from other races, 6.38% from two or more races. There were 4,715 households out of which 49.7% had children under the age of 18 living with them, 45.5% were married couples living together, 20.0% had a female householder with no husband present, 22.9% were non-families.

13.1% of all households were made up of individuals and 3.9% had someone living alone, 65 years of age or older. The average household size was 3.91 and the average family size was 4.10. In the CDP, the population was spread out with 34.9% under the age of 18, 15.7% from 18 to 24, 31.2% from 25 to 44, 14.1% from 45 to 64, 4.1% who were 65 years of age or older. The median age was 25 years. For every 100 females, there were 129.6 males. For every 100 females age 18 and over, there were 145.9 males. The median income for a household in the CDP was $24,315, the median income for a family was $22,628. Males had a median income of $17,875 versus $16,713 for females; the per capita income for the CDP was $8,576. About 34.6% of families and 39.8% of the population were below the poverty line, including 46.1% of those under age 18 and 26.9% of those age 65 or over. Being unincorporated, the area has no municipal government of its own and is governed by Collier County, Florida. Immokalee's public schools are operated by the District School Board of Collier County.

Elementary schools in Immokalee and serving Immokalee include Eden Park, Lake Trafford, Village Oaks. Pinecrest Elementary School, located outside of and adjacent to the CDP, serves a portion of the CDP. All residents are zoned to Immokalee Middle School and Immokalee High School, both located in the CDP. Immokalee Airport is a public-use airport located 1 mile northeast of the central business district. Collier Area Transit provides paratransit; the #5 connects to Naples, the #7 connects to Marco Island, the 8A circulates within the area. Immokalee used to be served by the Seaboard Coast Line Railroad which ran a branchline from Palmdale through Immokalee to Everglades City; the line used to generate considerable agricultural-related traffic. The rail line was cut back to Sunniland south of Immokalee in the 1950s and abandoned to the mainline at Palmdale in the 1980s; this left Immokalee without rail service. The main road through Immokalee is State Road 29. Other important county roads through the region are CR 29A and CR 846.

The federally recognized Seminole Tribe of Florida has one of its six reservations here, Immokalee, on which it operates one of its gaming casinos. The Audubon Society's Corkscrew Swamp Sanctuary is nearby. Immokalee is home to WCIW-LP, a low power community radio station owned and operated by the Coalition of Immokalee Workers; the station was built by numerous volunteers from Immokalee and around the country in December 2003 at the fifth Prometheus Radio Project barnraising. WCIW broadcasts music and public affairs to listeners in Spanish, Haitian Creole and several indigenous languages, including Mam and Kan. WAFZ-FM is a full-power FM radio station licensed to Immokalee, Florida; the station plays a variety of current hits in the Regional Mexican format. In the 1980s, WAFZ played Tejano music on its sister station WAFZ-AM. In its beginnings WAFZ had been WZOR-AM 1490 and English programming adult contemporary music and news in the morning and until 3pm, it changed its format to Regional Mexican/Tejano.

The early DJs that worked there were Gabino Soliz, "EL CHAVO ALEGRE" and Irma Ayala. The station continued on the air for a long time until the mid 1990s, when it went silent for a while until what is now WAFZ was bought by Glades Media Company LLC, transmitted what WAFZ-FM was playing; the current

Chief Apostle

The Chief Apostle is the highest minister in the New Apostolic Church, has existed since 1896. The term "Chief Apostle" was first used to describe Jesus Christ in the New Covenant Scriptures, Book of Hebrews, Chapter 3, verse 1, where he is called the High Priest; as far as the controversies regarding which of the remaining 11 12 and more apostles after that which includes Saul called Paul, Scripture itself does not say. It may well have been that they continued to follow the Messiah as their head. Indeed, what the Bible itself promotes; the following are other views on chief apostles and the religions that therefore must flow out of those beliefs. One system in common use today is used by Messianic apostles who believe James "the Just" was Chief Apostle, in Jerusalem, following Jesus return to his Father in Heaven. A similar system is used by Catholic churches worldwide, varying from Roman Catholics, to Anglican Catholics, to Coptic, Russian etc; each with a differing view on who is, or was, a Chief Apostle and sometimes now.

A similar view introduced by minister Friedrich Krebs and can be compared to the one Apostle Peter had 2,000 years ago amongst the original Apostles. Before Krebs introduced it, the title was used in the Catholic Apostolic Church, however with a different meaning. Former Chief Apostles: The function of the Chief Apostle is to lead the New Apostolic Church. On questions about the faith of New Apostolic Church members, he has the highest authority. Together with the district apostles he determines the policy of the church; the Chief Apostle can retire them. One of the most interesting Chief Apostles was J. G. Bischoff: at Christmas in 1950 he declared his "Botschaft"; this teaching announced that he would not die before Jesus Christ's return, during which the chosen people will be taken into His kingdom. In 1954 this teaching became official dogma; those ministers the apostles, who did not preach this message lost their positions and were excommunicated from the New Apostolic Church. The most important "victim" of this policy was Peter Kuhlen, the ordained successor to J.

G. Bischoff; when Chief Apostle Bischoff died in 1960, his dogma about Christ's return had not been fulfilled. In 2013, Chief Apostle Wilhelm Leber made a statement in which the position of the Church is reviewed and provides that the "message" represented a personal position of Apostle Bischoff; the various communities and congregations which evolved out of these conflicts in different countries gathered in 1956 to form the United Apostolic Church. Wikipedia Germany


Emetine is a drug used as both an anti-protozoal and to induce vomiting. It is produced from the ipecac root, it takes its name from its emetic properties. Mechanism of action of emetine was studied by François Magendie during the nineteenth century. Early use of emetine was in the form of oral administration of the extract of ipecac root, or ipecacuanha; this extract was thought to contain only one alkaloid, but was found to contain several, including cephaeline and others. Although this therapy was successful, the extract caused vomiting in many patients, which reduced its utility. In some cases, it was given with opioids to reduce nausea. Other approaches to reduce nausea involved coated tablets, allowing the drug to be released after digestion in the stomach; the identification of emetine as a more potent agent improved the treatment of amoebiasis. While use of emetine still caused nausea, it was more effective than the crude extract of ipecac root. Additionally, emetine could be administered hypodermically which still produced nausea, but not to the degree experienced in oral administration.

Although it is a potent antiprotozoal, the drug can interfere with muscle contractions, leading to cardiac failure in some cases. Because of this, in some uses it is required to be administered in a hospital so that adverse events can be addressed. Dehydroemetine is a synthetically produced antiprotozoal agent similar to emetine in its anti-amoebic properties and structure, but it produces fewer side effects. Cephaeline is a desmethyl analog of emetine found in ipecac root. Emetine dihydrochloro hydrate is used in the laboratory to block protein synthesis in eukaryotic cells, it does this by binding to the 40S subunit of the ribosome. This can thus be used in the study of protein degradation in cells. Mutants resistant to emetine are altered in the 40S ribosomal subunit, they exhibit cross-resistance to cryptopleurine, tylocrebrine and tubulosine, but not other inhibitors of protein synthesis; the compounds to which these mutants exhibit cross-resistance have been shown to share common structural determinants with emetine that are responsible for their biological activities.

The biosynthesis of cephaeline and emetine come from two main biosynthesis pathways: the biosynthesis of Dopamine from L-tyrosine and the biosynthesis of secologanin from geranyl diphosphate. Biosynthesis begins from the reaction between dopamine and secologanin forming N-deacetylisoipecoside and N-deacetylipecoside; the S-form goes through a Pictet-Spengler type reaction followed by a series of O-methylations and the removal of glucose, with O-methyltransferases and a glycosidase, to form proemetine. Proemetine reacts with another dopamine molecule to form 7'-O-demethylcephaeline; the final products are produced with a 7'-O-methylation to make cephaeline and a 6'-O-methylation successively to make emetine. Heavy or overusage of emetine can carry the risk of developing proximal myopathy and/or cardiomyopathy. A 2018 study at Princeton University and Thomas Jefferson University has demonstrated that emetine blocks the dissemination of rabies virus inside nerve cells, but the exact mechanism is still under investigation.

Emetine had no effect on the transport of endosomes devoid of the rabies virus.. But endosomes carrying the virus were either immobilized, or were only able to move short distances at slower-than-normal speeds. In 2016, a study found that low doses of emetine inhibited cytomegalovirus replication and was synergistic with ganciclovir

1st Helicopter Brigade

The 1st Helicopter Brigade is based at JGSDF Camp Kisarazu in Kisarazu, in Chiba Prefecture. An independent brigade, it was attached to the Central Readiness Force on March 28, 2007. Like most JGSDF units, the brigade's aircraft are deployed to conduct exercises from their Kisarazu base annually during the New Year period; the brigade would operate under the Ground Component Command as a supporting unit for the Central Readiness Regiment, 1st Airborne Brigade and the Japanese Special Forces Group if deployed into a combat zone. Prior to the brigade's integration into the Central Readiness Force, it had been involved in civil disaster operations in response to natural disasters such as forest fires and earthquakes; the 1st Helicopter Brigade was first established on March 20, 1959, by the Japan Ground Self-Defense Force Aviation School at JGSDF Camp Kasumigaura in Kasumigaura, Ibaraki. After the brigade was established, two helicopter companies were created on March 1, 1968, during a period of reorganization.

The 1st Helicopter Company was stationed at JGSDF Camp Kisarazu on March 22, 1968, with the 2nd Helicopter Company arriving on June 1, 1968. A special transport squad was established in the brigade on December 19, 1986. Another period of reorganization began on March 27, 2006, when a communications and reconnaissance squad was added to the unit. On March 28, 2007, the 1st Helicopter Brigade was formally incorporated into the Central Readiness Force; the brigade was deployed by the Central Readiness Force on its first operation to subdue wildfires in the forests of the Yamanashi Prefecture on April 29, 2007. They have been deployed on humanitarian operations in the aftermath of the March 2011 earthquake; the 1st Helicopter Brigade utilize the following aircraft for the Central Readiness Force: Headquarters Headquarters and Service Company 1st Transportation Helicopter Group 103rd Flight Squadron 104th Flight Squadron 105th Flight Squadron 106th Flight Squadron 102nd Flight Squadron Special transportation helicopter Squadron Communications and Reconnaissance Squadron Field Maintenance Party 1st Helicopter Brigade's Official CRF Page