The River Axe is a 22-mile (35 km) long river in the counties of Dorset, Somerset and Devon, in the south-west of England. It rises in Dorset and flows south to Lyme Bay which it enters through the Axe Estuary in Devon. It is a shallow, non-navigable river, although its mouth at Seaton has some boating activity. The name Axe derives from a Common Brittonic word meaning "abounding in fish", and is cognate with pysg, the Welsh word for fish.

Lyme Bay is an area of the English Channel off the south coast of England. The south western counties of Devon and Dorset front onto the bay.