Rizal Avenue, also known as Avenida or Avenida Rizal, is one of Manila's main thoroughfares running from its Santa Cruz and Quiapo districts to the Bonifacio Monument (Monumento) Circle in Caloocan. Named after the national hero José Rizal, it is a part of Radial Road 9 (R-9). The LRT Line 1 elevated railroad is built above the street in its entire length, and several jeepneys ply the area taking passengers from Caloocan, Quezon City, and Valenzuela. Most of the street is within Santa Cruz, Manila. By the 1960s, economic activities shifted from Binondo to Makati. The avenue forms part of National Route 150 (N150) of the Philippine highway network.

Santa Cruz is a district in the northern part of the City of Manila, Philippines, located on the right bank of the Pasig River near its mouth, bordered by the districts of Tondo, Binondo, Quiapo, and Sampaloc, as well as the areas of Grace Park and Barrio San Jose in Caloocan and the district of La Loma in Quezon City. The district belongs to the 3rd congressional district of Manila.