Robert Michael Urich was an American film, stage actor, television producer. Over the course of his 30-year career, he starred in a record 15 television series. Urich began his career in television in the early 1970s. After guest stints and roles in short-lived television series, he won a co-starring role in the action/crime drama series S. W. A. T. in 1975. In 1976, he landed the role of Dan Tanna in the crime drama series Vega$, it aired on ABC from 1978 to 1981, earned him two Golden Globe Award nominations. In addition to his work in television, he starred in several feature films, including Magnum Force, The Ice Pirates, Turk 182. From 1985 to 1988, he portrayed the title role in the detective television series Spenser: For Hire, based on Robert B. Parker's series of mystery novels. In 1988, he began hosting the documentary series National Geographic Explorer, he won a CableACE Award for his work on the series. He was awarded a Golden Boot Award for his work in Western television series and films.
In 1996, Urich starred in The Lazarus Man. It was canceled shortly after he announced that he had been diagnosed with synovial sarcoma, a rare cancer, in July that year, he sought treatment for his illness while continuing his career and worked to raise money for cancer research. He was declared cancer free in 1998 and returned to television in the UPN series, Love Boat: The Next Wave. In 2000, he made his Broadway debut as Billy Flynn in the musical Chicago, his last role was in the NBC sitcom Emeril in 2001, but in the autumn of that year, his cancer returned and he died in April 2002 at age 55. Urich was born and raised in Toronto, the son of John Paul and Cecilia Monica Urich, he raised Byzantine Catholic and Roman Catholic. Urich attended Florida State University on a football scholarship as a center, was a member of the Lambda Chi Alpha fraternity. In 1968, he earned a bachelor's degree in Television Communications, he went on to Michigan State University after working in Ohio to earn a master's degree in Broadcast Research and Management.
He worked as a salesman in Chicago at WGN-TV. He worked as a weatherman. After appearing in a production of The Rainmaker with Burt Reynolds, Urich decided to pursue acting full-time after Reynolds encouraged him to move to Los Angeles. Urich made his television debut in a guest starring role in The F. B. I. in 1972. The following year, he won a lead role in Ted & Alice, it was an adaptation of the 1969 film of the same title. It was canceled after six episodes, he made his film debut that same year opposite Clint Eastwood in the Dirty Harry film Magnum Force playing a vigilante motorcycle-patrol police officer. In 1975, Urich was cast in the action/crime drama series S. W. A. T.. According to the executive producer Aaron Spelling, Burt Reynolds convinced Spelling to allow Urich to read for the part. Spelling was impressed with his reading and cast him in the role of "Officer Jim Street". A mid-season replacement, it earned high enough ratings to warrant a second season. However, it was canceled in 1976 due to its violent content.
Urich's next role was on the sitcom Soap as Peter the Tennis Player in 1977. That same year he was cast as Paul Thurston, a good-looking, ego-driven talk show host in the Bewitched spin-off series Tabitha, starring Lisa Hartman, its ratings were strong, but schedule changes caused ratings to drop and it was canceled in 1978 after 13 episodes. Shortly after, he was cast in another Aaron Spelling produced series Vega$, he portrayed the series' lead character, Dan Tanna, a private detective who solves crimes in Las Vegas. It was a hit for ABC and he received two Golden Globe Award nominations for his work on it. By the third season, Urich had grown a bit tired of the role and complained about the declining quality of the script writing. Ratings had declined and it was canceled in June, 1981. Shortly after, he decided to focus on his film career, his first film for them was a science fiction piece directed by Alan Rudolph. Shortly after filming Endangered Species, Urich signed on to star in another series Gavilan.
He starred as the title character, a former CIA agent turned oceanographer. It was canceled after seven episodes. In 1984, he starred in two more films The Ice Pirates, Wes Craven's Invitation to Hell; the following year, Urich co-starred in Turk 182. It was a box office failure and he was nominated for a Golden Raspberry Award. In 1985, Urich returned to episodic television as the title character in Spenser: For Hire, it was another aired for three seasons. He reprised the role in several television films after it was canceled: Spenser: Ceremony, Spenser: Pale Kings and Princes, Spenser: The Judas Goat, Spenser: A Savage Place. In 1988, he began hosting the documentary series National Geographic Explorer, he won a CableACE Award for his work on the series. In 1989, he portrayed Jake Spoon in the acclaimed television miniseries Lonesome Dove, a role for which he received many positive reviews. In the 1990s, Urich appeared in television films and several short-lived television series. From 1990 to 1991, he starred in the TV movie 83 Hours'Til Dawn.
The following year, he starred in a drama series that aired on ABC for ten episodes. In 1993, he and Faye Dunaway starred, it was critically panned and canceled after four episodes. In 1995, he narrated an rare one-night showing of a Disney television documentary called Alien Encounters: From New Tomorrowland, it has never been shown
Bakersfield is a small residential suburb of Nottingham east of the city centre. Bakersfield was developed during the 1930s, with a mixture of private and council residential housing. A remarkable feature of the council housing is the space given over to gardens and other open spaces. Other amenities added included a supermarket, numerous smaller shops and a sub post-office. In common with most Nottingham developments of the time, housing was provided first, with other facilities being added later. Bakersfield lies on the eastern edge of Nottingham unitary authority, running up to the boundary with Gedling Borough Council, it is in the Nottingham East constituency for Westminster elections. Bakersfield occupies the eastern end of Dales ward, around Oakdale Road, it lies between the suburbs of Sneinton to the west, Carlton to the northeast, Colwick to the southeast. To the south is Colwick Woods, a large area of ancient woodland and green open space, leading down to the Nottingham Racecourse at Colwick.
There are panoramic views from the top of Colwick Woods, of the Trent Valley as far as Belvoir Castle and across the city to Wollaton and the Ratcliffe on Soar power station. A feature of the area is that many of the road names end in'dale', which sometimes causes confusion for first-time visitors. Bakersfield was once inhabited by post war Polish/Italian immigrants. Many of the Italian immigrants were prisoners of war who were held in the Prisoner of War camp situated on Colwick Woods. While Poles and Italians still have a presence here, It now has an increasing South Asian demographic. Bakersfield missed out on the great industrialisation of the 19th century and was created as a dormitory for commuters into Nottingham city centre; the Rio cinema on Oakdale Road opened in 1939 and closed due to the onslaught of television in 1959. It became a night club; the ground floor is used as a shop, called "Nisa Local" with the former balcony level as a snooker club, closed in November 2008, having since re-opened as a restaurant which has since closed.
There are a couple of a medical centre and a community centre. The former public house, The Oakdale, that used to greet you as you enter Bakersfield, stood on the original site of a large farm barn. Over the years it has been the centre of the local community and in the Second World War was a bomb shelter; the public house has now closed and the premised now house a Tesco Local store. Oakdale Road and the pub both get their name from a large oak tree that stood there till bad weather caused damage, it was deemed unsafe and had to be felled; the railway to Netherfield and Grantham runs along the A612 road on the southern edge of Bakersfield but the area has not had a station since the Racecourse station shut in 1959. Nottingham City Transport 43: Nottingham - Sneinton Dale - BakersfieldNottingham Minibus 73A: Netherfield - Bakersfield - Sneinton Some primary students attended Jesse Boot Primary School, Hereford Road, Parkdale Primary School, Parkdale Road. Comprehensive age students accessed schools around the immediate area, such as Greenwood Dale, Manvers Pierrepont, Carlton Road and further down Sneinton Road.
Further Education was at the Forest Fields College and as of the late 1990s in the now defunct Manvers Pierrepont Comprehensive, Carlton Road. The parish church of St John the Baptist at Carlton and St Stephen's on Sneinton Dale cover the area for the Church of England; the Church of St Cyprian on Marston Road, off Dale View Road, was built in 1913. Dales United Reformed Church was built in 1930. Nottingham Racecourse and Nottingham Greyhound Stadium lie on the southern edge of Bakersfield. There was a public pitch and putt course in Colwick Woods, closed some years ago. Jack Burkitt captained Nottingham Forest to their 1959 FA Cup win against Luton Town, he managed Notts County in 1966 and worked for Brian Clough at Derby for a few years before leaving football to take over Oakdale Road post office. Bakersfield - for other towns with the same name Dales ward official website
Suppressor of tumorigenicity 14 protein known as matriptase, is a protein that in humans is encoded by the ST14 gene. ST14 orthologs have been identified in most mammals. Matriptase is an integral membrane serine protease; this protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, is found to be activated by sphingosine-1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scatter factor, urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. Matriptase is a type II transmembrane serine protease expressed in most human epithelia, where it is coexpressed with its cognate transmembrane inhibitor, hepatocyte growth factor activator inhibitor -1. Activation of the matriptase zymogen requires sequential N-terminal cleavage, activation site autocleavage, transient association with HAI-1. Matriptase has an essential physiological role in profilaggrin processing, corneocyte maturation, lipid matrix formation associated with terminal differentiation of the oral epithelium and the epidermis, is critical for hair follicle growth.
Matriptase is an 80- to 90-kDa cell surface glycoprotein with a complex modular structure, common to all matriptases. The expression of this protease has been associated with breast, colon and ovarian tumors, which implicates its role in cancer invasion, metastasis. Matriptase and HAI expression are dysregulated in human cancer, matriptase expression, unopposed by HAI-1 potently promotes carcinogenesis and metastatic dissemination in animal models