Roberta S. Jacobson is an American diplomat who was the United States Ambassador to Mexico from June 2016 to May 2018. She previously served as the Assistant Secretary of State for Western Hemisphere Affairs from March 30, 2012, to May 5, 2016. The United States Senate approved her nomination as U.S. Ambassador to Mexico on April 28, 2016. In March 2018, Jacobson announced her resignation effective May 5. Foreign Policy reported on January 18, 2021 that Jacobson would be in charge of Mexico–United States border affairs at the National Security Council under President Joe Biden.

The Assistant Secretary of State for Western Hemisphere Affairs is the head of the Bureau of Western Hemisphere Affairs within the United States Department of State, the foreign affairs department of the United States federal government. The Assistant Secretary of State guides operation of the U.S. diplomatic establishment in the countries of the Western Hemisphere and advises the Secretary of State and the Under Secretary for Political Affairs.