Roderigo Lopes served as a physician-in-chief to Queen Elizabeth I of England from 1581 until his death by execution, having been found guilty of plotting to poison her. A Portuguese converso or New Christian of Jewish ancestry, he is the only royal doctor in English history to have been executed, and may have inspired the character of Shylock in Shakespeare's The Merchant of Venice, which was written within four years of his death.

The Jew of Malta is a play by Christopher Marlowe, written in 1589 or 1590. The plot primarily revolves around a Maltese Jewish merchant named Barabas. The original story combines religious conflict, intrigue, and revenge, set against a backdrop of the struggle for supremacy between Spain and the Ottoman Empire in the Mediterranean that takes place on the island of Malta. There has been extensive debate about the play's portrayal of Jews and how Elizabethan audiences would have viewed it.