The Archdiocese of Avignon is a Latin archdiocese of the Catholic Church in France. The diocese exercises jurisdiction over the territory embraced by the department of Vaucluse, in the Region of Provence-Alpes-Côte d'Azur. It is named for the prefecture of Avignon. The diocese has been led since January 2021 by Archbishop Georges Pontier, whom Pope Francis called out of retirement to serve as Apostolic Administrator.

The former French Catholic diocese of Apt, in southeast France, existed from the fourth century until the French Revolution. By the Concordat of 1801, it was suppressed, and its territory was divided between the diocese of Digne and the diocese of Avignon. Its seat was at Apt Cathedral, in Vaucluse.