The Archdiocese of Avignon is a Latin archdiocese of the Catholic Church in France. The diocese exercises jurisdiction over the territory embraced by the department of Vaucluse, in the Region of Provence-Alpes-Côte d'Azur. It is named for the prefecture of Avignon. The diocese has been led since January 2021 by Archbishop Georges Pontier, whom Pope Francis called out of retirement to serve as Apostolic Administrator.

Avignon is the prefecture of the Vaucluse department in the Provence-Alpes-Côte d'Azur region of southeastern France. Located on the left bank of the river Rhône, the commune had a population of 93,671 as of the census results of 2017, with about 16,000 living in the ancient town centre enclosed by its medieval walls. It is France's 35th-largest metropolitan area according to INSEE with 337,039 inhabitants (2020), and France's 13th-largest urban unit with 459,533 inhabitants (2020). Its urban area was the fastest-growing in France from 1999 until 2010 with an increase of 76% of its population and an area increase of 136%. The Communauté d'agglomération du Grand Avignon, a cooperation structure of 16 communes, had 197,102 inhabitants in 2022.